Implementation of polygenic risk score guided breast cancer precision prevention

About this project

<p style="text-align: justify">Antegenes is a healthcare technology company developing and implementing innovative genetic tests&nbsp;based on polygenic risk score technology to enable personalised prevention of common cancers.&nbsp;</p> <p style="text-align: justify"><span style="font-size: 10pt"><span style="font-family: Verdana, sans-serif">Breast cancer screening in EU contries is only age-based but mortality could be decreased by around 20% if screening programmes would consider AnteBC individual test results. However, as European healthcare markets are heavily fragmented and regulated, population-wide adoption of a new solution requires public reimbursement to end-users. Clinical adoption requires proof of clinical utility and feasibility of its use in the local medical setting. Project promoter OÜ Antegenes has registered a polygenic breast cancer (BC) risk test, AnteBC as an CE-certified medical device.</span></span></p> <p style="text-align: justify"><span style="font-size: 10pt"><span style="font-family: Verdana, sans-serif">The objective of the project is to collect clinical utility and performance evidence on the Antegenes breast cancer risk test (AnteBC) in scientific studies, to drive the clinical adoption with a feasibility pilot of AnteBC in Norwegian medical settings and to generate technical documentation for preparing a Norwegian reimbursement application.</span></span></p> <p style="text-align: justify"><span style="font-size: 10pt"><span style="font-family: Verdana, sans-serif">Project consortium brings in the best scientific expertise within Norway to assess the performance and utility of our tests for the local settings, one of the largest hospital trusts to apply this in a clinical practice and a well-connected cancer knowledge cluster to communicate the project outputs to drive further engagement in the local stakeholder community. A novel healthcare application with Estonian source in the Norwegian health system provides a platform for developing mutual professional partnerships between all the project partners and also with external parties engaged via dissemination activities.&nbsp;</span></span></p>

Bilateral cooperation results

The Partners contributed to the implementation of the project tasks according to plan. We managed to involve all partners and collaborate successfully. The cooperation in the project laid the foundation for broader cooperation in the future, for which follow-up projects are also already being planned.

Project partners

• University of Oslo Donor project partner· Norway
• Oslo Cancer Cluster SA Donor project partner· Norway
• Oslo University Hospital, Cancer Registry of Norway Donor project partner· Norway
• Vestre Viken HF Donor project partner· Norway